Regional Differences in Arachidonic Acid Release in Rat Hippocampal CA1 and CA3 Regions during Cerebral Ischemia | Zendy

Eva Westerberg | Zendy; Jayant K. Deshpande | Zendy; Tadeusz Wieloch | Zendy

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Regional Differences in Arachidonic Acid Release in Rat Hippocampal CA₁ and CA₃ Regions during Cerebral Ischemia

Author(s) -

Eva Westerberg,

Jayant K. Deshpande,

Tadeusz Wieloch

Publication year - 1987

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1987.43

Subject(s) - arachidonic acid , ischemia , phospholipase a2 , hippocampal formation , hippocampus , calcium , phospholipase , endocrinology , medicine , agonist , chemistry , brain ischemia , biology , biochemistry , enzyme , receptor

Changes in the levels of arachidonic acid during ischemia in selectively vulnerable areas of the hippocampus were studied in the rat brain. Since neurons in the CA, region are more vulnerable to ischemia than neurons in the adjacent CA 3 region, the release of arachidonic acid in these two regions was measured during decapitation ischemia of 4- to 12-min duration. The concentration of free arachidonic acid increased with the duration of ischemia in both regions. However, the level was significantly higher in CA 1 , than in CA 3 after 8 and 12 min of ischemia. This difference in arachidonic acid accumulation may reflect differences between the regions in agonist-dependent phospholipid breakdown as well as calcium-dependent phospholipase activity. The importance for the development of neuronal necrosis is discussed.

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