Intracellular and Extracellular Spaces of Normal Adult Rat Brain Determined from the Proton Nuclear Magnetic Resonance Relaxation Times | Zendy

Munetaka Haida | Zendy; Masahiro Yamamoto | Zendy; H. Matsumura | Zendy; Yukito Shinohara | Zendy; Minoru Fukuzaki | Zendy

Open Access

Intracellular and Extracellular Spaces of Normal Adult Rat Brain Determined from the Proton Nuclear Magnetic Resonance Relaxation Times

Author(s) -

Munetaka Haida,

Masahiro Yamamoto,

H. Matsumura,

Yukito Shinohara,

Minoru Fukuzaki

Publication year - 1987

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1987.104

Subject(s) - extracellular , intracellular , nuclear magnetic resonance , relaxation (psychology) , magnetic resonance imaging , proton , chemistry , brain tissue , biophysics , neuroscience , medicine , physics , biology , biochemistry , radiology , quantum mechanics

The nuclear magnetic resonance method was used to investigate the state of water molecules in normal rat brain tissue in vitro. The transverse magnetization decay curve (TMDC) of the fresh brain tissue of adult rats (8- or 10-weeks-old) was biexponential, which could be interpreted in terms of two distinct transverse relaxation times ( T 2 ). Several factors that may affect the TMDC are discussed. It was concluded that the fast and slow components of T 2 correspond to those of the water molecules of the intracellular and the extracellular spaces of normal rat brain tissue, respectively.

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