Tomographic Mapping of Kinetic Rate Constants in the Fluorodeoxyglucose Model Using Dynamic Positron Emission Tomography | Zendy

Hiroshi Sasaki | Zendy; Iwao Kanno | Zendy; Matsutaro Murakami | Zendy; F Shishido | Zendy; Kazuo Uemura | Zendy

Open Access

Tomographic Mapping of Kinetic Rate Constants in the Fluorodeoxyglucose Model Using Dynamic Positron Emission Tomography

Author(s) -

Hiroshi Sasaki,

Iwao Kanno,

Matsutaro Murakami,

F Shishido,

Kazuo Uemura

Publication year - 1986

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1986.78

Subject(s) - positron emission tomography , fluorodeoxyglucose , reaction rate constant , nuclear medicine , positron , pixel , tomography , constant (computer programming) , materials science , chemistry , physics , analytical chemistry (journal) , mathematics , kinetics , computer science , optics , medicine , nuclear physics , chromatography , programming language , quantum mechanics , electron

A quick computing algorithm to calculate the rate constants (k*1, k*2, k*3) in the [18F]2-fluoro-2-deoxy-D-glucose (FDG) model was developed. The algorithm solved for the rate constants pixel by pixel using a conventional least-squares method and two tables consisting of a set of various rate constants, to shorten the computing time. Five planes of rate constant images were obtained. A combined study using the dynamic FDG method and the 15O-labeled gas continuous inhalation method was performed on seven healthy male volunteers aged 26-35 years. Results indicated an apparent discrepancy between CMRglu and CMRO2 in the cerebellum, where the low glucose utilization was correlated with a low FDG phosphorylation rate (k*3) despite a sufficient FDG transportation rate (k*1) from plasma to tissue.

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