Sequential Assessment of Regional Cerebral Blood Flow, Regional Cerebral Blood Volume, and Blood—Brain Barrier in Focal Cerebral Ischemia: A Case Report | Zendy

Vittorio Di Piero | Zendy; Daniela Perani | Zendy; Annarita Savi | Zendy; P. Gerundini | Zendy; G Lenzi | Zendy; F. Fazio | Zendy

Open Access

Sequential Assessment of Regional Cerebral Blood Flow, Regional Cerebral Blood Volume, and Blood—Brain Barrier in Focal Cerebral Ischemia: A Case Report

Author(s) -

Vittorio Di Piero,

Daniela Perani,

Annarita Savi,

P. Gerundini,

G Lenzi,

F. Fazio

Publication year - 1986

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1986.62

Subject(s) - cerebral blood flow , medicine , perfusion , cerebral perfusion pressure , ischemia , emission computed tomography , single photon emission computed tomography , cerebral blood volume , blood–brain barrier , blood flow , blood volume , stroke (engine) , perfusion scanning , cardiology , nuclear medicine , anesthesia , central nervous system , mechanical engineering , engineering

Regional CBF (rCBF) and regional cerebral blood volume (rCBV) were evaluated by N,N,N'-trimethyl-N'-(2)-hydroxy-3-methyl-5-[123I]iodobenzyl-1, 3-propanediamine-2 HCl- and 99mTC-labeled red blood cells, respectively, and single-photon emission computerized tomography (SPECT) in a patient with focal cerebral ischemia. Sequential transmission computerized tomography (TCT) and SPECT functional data were compared with clinical findings to monitor the pathophysiological events occurring in stroke. A lack of correlation between rCBF-rCBV distributions and blood-brain barrier (BBB) breakdown was found in the acute phase. In the face of more prolonged alteration of BBB, as seen by TCT enhancement, a rapid evolution of transient phenomena such as luxury perfusion was shown by SPECT studies. Follow-up of the patient demonstrated a correlation between the neurological recovery and a parallel relative improvement of the cerebral perfusion.

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