Two-Day Starvation Does Not Alter the Kinetics of Blood-Brain Barrier Transport and Phosphorylation of Glucose in Rat Brain | Zendy

Paul D. Crane | Zendy; William M. Pardridge | Zendy; Leon D. Braun | Zendy; William H. Oldendorf | Zendy

Open Access

Two-Day Starvation Does Not Alter the Kinetics of Blood-Brain Barrier Transport and Phosphorylation of Glucose in Rat Brain

Author(s) -

Paul D. Crane,

William M. Pardridge,

Leon D. Braun,

William H. Oldendorf

Publication year - 1985

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1985.6

Subject(s) - phosphorylation , starvation , glucose transporter , blood–brain barrier , endocrinology , medicine , carbohydrate metabolism , metabolism , kinetics , cerebral blood flow , chemistry , biology , central nervous system , biochemistry , insulin , physics , quantum mechanics

The blood-brain barrier (BBB) transport and brain phosphorylation of glucose were assessed in conscious rats subjected to 2 days of starvation. Although plasma glucose decreased, no significant changes in brain blood flow, BBB glucose transport, or 2-deoxy-d-glucose phosphorylation were observed. The data suggest that adaptive changes of brain glucose metabolism previously observed in starvation are located beyond the initial steps of brain entry and phosphorylation.

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