Rapid Amino Acid Uptake in Rat Pituitary Neural Lobe during Functional Stimulation by Chronic Dehydration | Zendy

Paul M. Gross | Zendy; Ronald G. Blasberg | Zendy; Joseph D. Fenstermacher | Zendy; Clifford S. Patlak | Zendy

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Rapid Amino Acid Uptake in Rat Pituitary Neural Lobe during Functional Stimulation by Chronic Dehydration

Author(s) -

Paul M. Gross,

Ronald G. Blasberg,

Joseph D. Fenstermacher,

Clifford S. Patlak

Publication year - 1985

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1985.19

Subject(s) - stimulation , amino acid , medicine , endocrinology , dehydration , chemistry , lobe , pituitary gland , membrane , biochemistry , biology , hormone , anatomy

We studied the transfer of a small neutral amino acid, α-aminoisobutyric acid, from arterial blood into the pituitary neural lobe in normal rats and in rats deprived of water for 5 days. A threefold increase in the neural lobe uptake of the amino acid was found in the chronically dehydrated rats. Possible causes for this effect include enlargement of the capillary and pituicyte membrane surface areas available for solute flux and increased permeability of these membranes. Such functional and structural alterations may be associated with an increase in protein turnover in the neural lobe during dehydration.

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