Effects of Xenon and Krypton on Regional Cerebral Blood Flow in the Rat | Zendy

Larry Junck | Zendy; Vijay Dhawan | Zendy; Howard T. Thaler | Zendy; David A. Rottenberg | Zendy

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Effects of Xenon and Krypton on Regional Cerebral Blood Flow in the Rat

Author(s) -

Larry Junck,

Vijay Dhawan,

Howard T. Thaler,

David A. Rottenberg

Publication year - 1985

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1985.16

Subject(s) - xenon , cerebral blood flow , inhalation , krypton , nuclear medicine , anesthesia , blood flow , medicine , chemistry , cardiology , organic chemistry

The effects of high inspired concentrations of xenon and krypton on regional CBF (rCBF) were assessed in the rat using [ 14 C]iodoantipyrine and quantitative autoradiography. Inhalation of 80% xenon for 1 or 2 min and inhalation of 40% xenon for 2 min were found to have significant effects on rCBF, including average increases of 75–96% in cerebral neocortical regions. Inhalation of 40% xenon for 1 min and of 80% krypton for 2 min had no significant effect on rCBF in most brain regions studied. If xenon inhalation produces effects on rCBF in humans similar to those observed in the rat, such effects could be an important source of error in xenon computed tomography rCBF studies.

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