Effects of Cholecystokinin Octapeptide on Pial Arteriolar Diameter

The effects of the perivascular microapplication of sulphated cholecystokinin octapeptide (CCK-8) on pial arteriolar calibre have been examined in anaesthetised cats using a video-display image-splitting technique. The microinjection of CCK-8 (10 −10 –10 −6 M) did not alter significantly the calibre of the pial arterioles. The presence of CCK-8 (10 −7 M) in the injectate did not modify the constriction or dilatation of pial arterioles provoked by the perivascular microinjection of alkalotic (pH 7.45) or acidic (pH 6.8) artificial CSFs, respectively. Thus, although CCK-8-immunoreactive neuronal processes are known to be associated with cortical blood vessels, CCK-8 appears to have minimal vasomotor effects on pial vessels.