Dependency of Blood Flow Velocity in the Middle Cerebral Artery on End-Tidal Carbon Dioxide Partial Pressure—A Transcranial Ultrasound Doppler Study | Zendy

Thomas-Marc Markwalder | Zendy; P. Grolimund | Zendy; Rolf W. Seiler | Zendy; Fritz Roth | Zendy; Rune Aaslid | Zendy

Open Access

Dependency of Blood Flow Velocity in the Middle Cerebral Artery on End-Tidal Carbon Dioxide Partial Pressure—A Transcranial Ultrasound Doppler Study

Author(s) -

Thomas-Marc Markwalder,

P. Grolimund,

Rolf W. Seiler,

Fritz Roth,

Rune Aaslid

Publication year - 1984

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1984.54

Subject(s) - middle cerebral artery , pco2 , transcranial doppler , cerebral blood flow , blood flow , cerebral arteries , medicine , anesthesia , carbon dioxide , ultrasound , hemodynamics , cardiology , ischemia , radiology , chemistry , organic chemistry

The end-tidal carbon dioxide partial pressure (PCO 2 ) response curves for the flow velocity in the middle cerebral artery were studied in 31 normal subjects with transcranial Doppler techniques. An exponential curve with an exponent of 0.034 mm Hg −1 was found to be a good fit to the recorded data. By means of this relationship, recordings of flow velocity in cerebral arteries can be normalized to a standard value of PCO 2 . Physiological aspects of cerebrovascular reactivity to PCO 2 and the clinical implications of the PCO 2 response curve are discussed. The normal material provides a reference for assessing pathological responses.

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