Measurement of Blood—Brain Barrier Permeability with Positron Emission Tomography and [68Ga]EDTA | Zendy

Robert Kessler | Zendy; J. C. Goble | Zendy; Jonathan Bird | Zendy; Mary Girton | Zendy; J L Doppman | Zendy; С. И. Рапопорт | Zendy; J. A. Barranger | Zendy

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Measurement of Blood—Brain Barrier Permeability with Positron Emission Tomography and [⁶⁸Ga]EDTA

Author(s) -

Robert Kessler,

J. C. Goble,

Jonathan Bird,

Mary Girton,

J L Doppman,

С. И. Рапопорт,

J. A. Barranger

Publication year - 1984

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1984.48

Subject(s) - positron emission tomography , permeability (electromagnetism) , blood–brain barrier , positron , radiochemistry , nuclear medicine , materials science , nuclear magnetic resonance , physics , chemistry , nuclear physics , medicine , membrane , electron , central nervous system , biochemistry

Positron emission tomography (PET) was employed to examine time-dependent changes in blood-brain barrier (BBB) permeability to [68Ga]ethylenediaminetetraacetate (EDTA) in the rhesus monkey, following reversible barrier opening by intracarotid infusion of a hypertonic mannitol solution. The PET technique, when combined with measurements of plasma radioactivity, provided a quantitative measure of the cerebrovascular permeability-area product (PA) at different times following mannitol infusion. Hypertonic mannitol treatment reversibly increased PA to [68Ga]EDTA more than 10-fold; much of the barrier effect was over by 10 min after mannitol treatment. The results show that PET can be used to measure transient changes in BBB integrity in specific brain regions, under in vivo, noninvasive conditions.

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