Inhibition by Verapamil of Ischemic Ca2+ Uptake in the Rabbit Hippocampus | Zendy

Henrik Hagberg | Zendy; Anders Lehmann | Zendy; Anders Hamberger | Zendy

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Inhibition by Verapamil of Ischemic Ca²⁺ Uptake in the Rabbit Hippocampus

Author(s) -

Henrik Hagberg,

Anders Lehmann,

Anders Hamberger

Publication year - 1984

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1984.41

Subject(s) - verapamil , hippocampus , rabbit (cipher) , neuroscience , calcium , pharmacology , chemistry , medicine , biology , computer science , computer security

In the study described here a perfusion-dialysis system was used for recording ionic changes in the hippocampus during ischemia. Local perfusion with a Ca2+ entry blocker (verapamil) inhibited the fall in extracellular Ca2+ concentration which occurs in ischemia. The data consequently suggest that intracellular Ca2+ accumulation during ischemia can be blocked. A Ca2+ antagonist such as verapamil may thus improve post-ischemic neuronal recovery via a direct effect on parenchymal cells in addition to the previously suggested vascular effects.

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