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Using dynamic [ 18 F]fluorodeoxyglucose (FDG) positron emission tomography with a high-resolution, seven-slice positron camera, the kinetic constants of the original three-compartment model of Sokoloff and co-workers (1977) were determined in 43 distinct topographic brain regions of seven healthy male volunteers aged 28–38 years. Regional averages of the cerebral metabolic rate for glucose (CMR glu ) were calculated both from individually fitted rate constants (CMR glu kinetic) and from activity maps recorded 30–40 min after FDG injection, employing a four-parameter operational equation with standard rate constants from the literature (CMR glu autoradiographic). Metabolic rates and kinetic constants varied significantly among regions and subjects, but not between hemispheres. k 1  ranged between 0.0485 ± 0.00778 min −1  in the oval center and 0.0990 ± 0.01347 min −1  in the primary visual cortex. k 2  ranged from 0.1198 ± 0.01533 min −1  in the temporal white matter to 0.1472 ± 0.01817 min −1  in the cerebellar dentate nucleus. k 3  was lowest (0.0386 ± 0.01482 min −1 ) in temporal white matter and highest (0.0823 ± 0.02552 min −1 ) in the caudate nucleus. Maximum likelihood cluster analysis revealed four homogeneous groups of brain regions according to their respective kinetic constants: (1) white matter and mixed brainstem structures; (2) cerebellar gray matter and hippocampal formations; (3) basal ganglia and frontolateral and primary visual cortex; and (4) other cerebral cortex and thalamus. Across the entire brain, k 1  and k 2  were positively correlated (r = 0.79); k 1  and k 3  showed some correlation (r = 0.59); but no significant linear association was found between k 2  and k 3 . A strong correlation with CMR glu  could be demonstrated for k 1  (r = 0.88) and k 3  (r = 0.90), but k 2  was loosely correlated (r = 0.56). CMR glu  kinetic ranged from 17.0 ± 2.45 μmol/100 g/min in the occipital white matter to 41.1 ± 5.62 μmol/100 g/min in the frontolateral cortex. In most regions the mean values of CMR glu  kinetic did not differ significantly from CMR glu  autoradiographic. With few exceptions, however, within-region variance was significantly less for CMR glu  kinetic than for CMR glu  autoradiographic, suggesting greater individual reliability of results obtained by the kinetic approach.

journal of cerebral blood flow and metabolism

Regional Kinetic Constants and Cerebral Metabolic Rate for Glucose in Normal Human Volunteers Determined by Dynamic Positron Emission Tomography of [<sup>18</sup>F]-2-Fluoro-2-Deoxy-D-Glucose

Regional Kinetic Constants and Cerebral Metabolic Rate for Glucose in Normal Human Volunteers Determined by Dynamic Positron Emission Tomography of [18F]-2-Fluoro-2-Deoxy-D-Glucose

Regional Kinetic Constants and Cerebral Metabolic Rate for Glucose in Normal Human Volunteers Determined by Dynamic Positron Emission Tomography of [¹⁸F]-2-Fluoro-2-Deoxy-D-Glucose