Regional Cerebral Blood Flow in Conscious Stroke-Prone Spontaneously Hypertensive Rats | Zendy

K. Fredriksson | Zendy; Martin Ingvar | Zendy; Barbro B. Johansson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Regional Cerebral Blood Flow in Conscious Stroke-Prone Spontaneously Hypertensive Rats

Author(s) -

K. Fredriksson,

Martin Ingvar,

Barbro B. Johansson

Publication year - 1984

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1984.13

Subject(s) - cerebral blood flow , blood pressure , medicine , hemodynamics , putamen , stroke (engine) , blood flow , mean arterial pressure , cardiology , vascular resistance , anesthesia , heart rate , mechanical engineering , engineering

Regional cerebral blood flow (rCBF) was measured autoradiographically with [14C]iodoantipyrine as a diffusible tracer in two strains of conscious normotensive rats (Wistar Kyoto and local Wistar) and in two groups of spontaneously hypertensive stroke-prone rats (SHRSP) with a mean arterial pressure (MAP) below or above 200 mm Hg. In spite of the large differences in arterial pressure, rCBF did not differ significantly between the hypertensive and the normotensive groups in any of the 14 specified brain structures measured. However, rCBF increased asymmetrically within part of the caudate-putamen in two of nine SHRSP with a MAP above 200 mm Hg, indicating a regional drop in the elevated cerebrovascular resistance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research