The in vivo Autoradiographic Measurement of Regional Cerebral Blood Flow Using Stable Xenon and Computerized Tomography: The Effect of Tissue Heterogeneity and Computerized Tomography Noise | Zendy

David A. Rottenberg | Zendy; Han Lü | Zendy; Kimberlee J. Kearfott | Zendy

Open Access

The in vivo Autoradiographic Measurement of Regional Cerebral Blood Flow Using Stable Xenon and Computerized Tomography: The Effect of Tissue Heterogeneity and Computerized Tomography Noise

Author(s) -

David A. Rottenberg,

Han Lü,

Kimberlee J. Kearfott

Publication year - 1982

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1982.16

Subject(s) - cerebral blood flow , tomography , white matter , brain tissue , artifact (error) , medicine , noise (video) , blood flow , nuclear medicine , biomedical engineering , radiology , neuroscience , computer science , magnetic resonance imaging , artificial intelligence , biology , image (mathematics)

We have studied the effect of brain tissue (gray matter-white matter) heterogeneity and computerized tomography (CT) noise on the accuracy of xenon CT measurements of regional cerebral blood flow (rCBF) based upon "autoradiographic" and multiple-scan washin protocols. The results of our mathematical analysis indicate that both protocols are associated with a variety of measurement errors that lead to unacceptable and, to a large extent, unpredictable uncertainties in calculated values of rCBF. Brain tissue heterogeneity and high volumetric flow rates may--even in the absence of movement artifact and CT noise--lead to measurement errors in excess of 20%. Moreover, CT noise is additive in regard to these errors, and constitutes the most confounding variable of all.

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