A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption | Zendy

Rafael Calixto Bortolin | Zendy; Amanda Rodrigues de Vargas | Zendy; Juciano Gasparotto | Zendy; Paloma R Chaves | Zendy; C Schnorr | Zendy; Kd B Martinello | Zendy; Alexandre Kléber Silveira | Zendy; Thallita Kelly Rabelo | Zendy; Daniel Pens Gelain | Zendy; Julia Moreira | Zendy

Open Access

A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption

Author(s) -

Rafael Calixto Bortolin,

Amanda Rodrigues de Vargas,

Juciano Gasparotto,

Paloma R Chaves,

C Schnorr,

Kd B Martinello,

Alexandre Kléber Silveira,

Thallita Kelly Rabelo,

Daniel Pens Gelain,

Julia Moreira

Publication year - 2017

Publication title -

international journal of obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.663

H-Index - 225

eISSN - 1476-5497

pISSN - 0307-0565

DOI - 10.1038/ijo.2017.225

Subject(s) - cafeteria , obesity , dysbiosis , gut flora , western diet , metabolic syndrome , endocrinology , medicine , physiology , biology , immunology , pathology

Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public-health concern. Animal models of diet-induced obesity (DIO) are frequently used to study obesity, but which DIO model most accurately reflects the pathology of human obesity remains unclear. In this study, we designed a diet based on the human Western diet (WD) and compared it with the cafeteria diet (CAF) and high-fat diet (HFD) in order to evaluate which diet most closely mirrors human obesity.

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