Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies | Zendy

Caren E. Smith | Zendy; Julius S. Ngwa | Zendy; Toshiko Tanaka | Zendy; Q. Qi | Zendy; Mary K. Wojczynski | Zendy; Rozenn N. Lemaître | Zendy; Jennifer S. Anderson | Zendy; Ani Manichaikul | Zendy; Vera Mikkilä | Zendy; Frank J.A. van Rooij | Zendy; Z. Ye | Zendy; Stefania Bandinelli | Zendy; Alexis C. Wood | Zendy; Denise K. Houston | Zendy; Joshua Shulman | Zendy; Claudia Langenberg | Zendy; Nicola M. McKeown | Zendy; Dariush Mozaffarian | Zendy; Kari E. North | Zendy; Jorma Viikari | Zendy; M. Carola Zillikens | Zendy; Luc Djoussé | Zendy; Albert Hofman | Zendy; Mika Kähönen | Zendy; Edmond K. Kabagambe | Zendy; Ruth J. F. Loos | Zendy; Georgia Saylor | Zendy; Nita G. Forouhi | Zendy; Y. Liu | Zendy; Kenneth J. Mukamal | Zendy; Y-DI Chen | Zendy; Michael Y. Tsai | Zendy; André G. Uitterlinden | Zendy; Olli T. Raitakari | Zendy; Cornelia M. van Duijn | Zendy; Donna K. Arnett | Zendy; Ingrid B. Borecki | Zendy; L. Adrienne Cupples | Zendy; Luigi Ferrucci | Zendy; Stephen B. Kritchevsky | Zendy; Terho Lehtimäki | Zendy; Lu Qi | Zendy; Jerome I. Rotter | Zendy; David S. Siscovick | Zendy; Nicholas J. Wareham | Zendy; J.C.M. Witteman | Zendy; José M. Ordovás | Zendy; Jennifer A. Nettleton | Zendy

Open Access

Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies

Author(s) -

Caren E. Smith,

Julius S. Ngwa,

Toshiko Tanaka,

Q. Qi,

Mary K. Wojczynski,

Rozenn N. Lemaître,

Jennifer S. Anderson,

Ani Manichaikul,

Vera Mikkilä,

Frank J.A. van Rooij,

Z. Ye,

Stefania Bandinelli,

Alexis C. Wood,

Denise K. Houston,

Joshua Shulman,

Claudia Langenberg,

Nicola M. McKeown,

Dariush Mozaffarian,

Kari E. North,

Jorma Viikari,

M. Carola Zillikens,

Luc Djoussé,

Albert Hofman,

Mika Kähönen,

Edmond K. Kabagambe,

Ruth J. F. Loos,

Georgia Saylor,

Nita G. Forouhi,

Y. Liu,

Kenneth J. Mukamal,

Y-DI Chen,

Michael Y. Tsai,

André G. Uitterlinden,

Olli T. Raitakari,

Cornelia M. van Duijn,

Donna K. Arnett,

Ingrid B. Borecki,

L. Adrienne Cupples,

Luigi Ferrucci,

Stephen B. Kritchevsky,

Terho Lehtimäki,

Lu Qi,

Jerome I. Rotter,

David S. Siscovick,

Nicholas J. Wareham,

J.C.M. Witteman,

José M. Ordovás,

Jennifer A. Nettleton

Publication year - 2013

Publication title -

international journal of obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.663

H-Index - 225

eISSN - 1476-5497

pISSN - 0307-0565

DOI - 10.1038/ijo.2012.215

Subject(s) - lrp1 , genotype , waist , single nucleotide polymorphism , body mass index , medicine , endocrinology , clinical nutrition , population , biology , ldl receptor , lipoprotein , genetics , cholesterol , gene , environmental health

Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids.

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