Open AccessThe effects of weight cycling on lifespan in male C57BL/6J mice
Author(s) -
Edward O. List,
Darlene E. Berryman,
Jacob Wright-Piekarski,
Adam Jara,
Kevin Funk,
John J. Kopchick
Publication year - 2012
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/ijo.2012.203
Subject(s) - weight loss , cycling , medicine , endocrinology , obesity , overweight , weight change , leptin , weight gain , longevity , body weight , zoology , biology , gerontology , archaeology , history
With the increasing rates of obesity, many people diet in an attempt to lose weight. As weight loss is seldom maintained in a single effort, weight cycling is a common occurrence. Unfortunately, reports from clinical studies that have attempted to determine the effect of weight cycling on mortality are in disagreement, and to date, no controlled animal study has been performed to assess the impact of weight cycling on longevity. Therefore, our objective was to determine whether weight cycling altered lifespan in mice that experienced repeated weight gain and weight loss throughout their lives.