Open AccessAltered hypothalamic function in diet-induced obesity
Author(s) -
Lı́cio A. Velloso,
Michael W. Schwartz
Publication year - 2011
Publication title -
international journal of obesity
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/ijo.2011.56
Subject(s) - energy homeostasis , obesity , caloric theory , endocrinology , hypothalamus , homeostasis , medicine , food intake , energy expenditure , caloric intake , hormone , biology , neuroscience
Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic neurons that transduce hormonal, nutrient and neuronal signals into responses that ultimately match caloric intake to energy expenditure and thereby promote stability of body fat stores. Growing evidence suggests that rather than reflecting a failure to regulate caloric intake, common forms of obesity involve fundamental changes to this homeostatic system that favor the defense of an elevated level of body adiposity. This article reviews emerging evidence that during high-fat feeding, obesity pathogenesis involves fundamental alteration of hypothalamic systems that regulate food intake and energy expenditure.