Open AccessHuman growth hormone receptor (GHR) expression in obesity: I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women
Author(s) -
Ayşegül Erman,
Alain Veilleux,
André Tchernof,
Cynthia G. Goodyer
Publication year - 2011
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/ijo.2011.23
Subject(s) - growth hormone receptor , medicine , endocrinology , adipose tissue , obesity , adipocyte , receptor , biology , hormone , growth hormone
Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression.