Open AccessMitochondrial lipid oxidation is impaired in cultured myotubes from obese humans
Author(s) -
Kristen E. Boyle,
Donghai Zheng,
Ethan J. Anderson,
P. Darrell Neufer,
Joseph A. Houmard
Publication year - 2011
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/ijo.2011.201
Subject(s) - medicine , endocrinology , mitochondrion , biology , skeletal muscle , lipid metabolism , myogenesis , mitochondrial dna , lipid oxidation , respiration , biochemistry , anatomy , gene , antioxidant
The skeletal muscle of obese humans is characterized by an inability to appropriately respond to alterations in substrate availability. The purpose of this study was to determine if this metabolic inflexibility with obesity is retained in mitochondria of human skeletal muscle cells raised in culture (HSkMC) and to identify potential mechanisms involved.