Open AccessGenes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA
Author(s) -
Christina Holzapfel,
Harald Grallert,
Cornelia Huth,
Simone Wahl,
Beate Fischer,
Angela Döring,
Rückert Im,
Anke Hinney,
Johannes Hebebrand,
Wenwu He,
Hans Hauner,
Thomas Illig,
IM Heid
Publication year - 2010
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/ijo.2010.79
Subject(s) - body mass index , obesity , single nucleotide polymorphism , genetic association , demography , fto gene , medicine , snp , genome wide association study , polymorphism (computer science) , population , allele , genetics , genotype , biology , gene , environmental health , sociology
Data from meta-analyses of genome-wide association studies provided evidence for an association of polymorphisms with body mass index (BMI), and gene expression results indicated a role of these variants in the hypothalamus. It was consecutively hypothesized that these associations might be evoked by a modulation of nutritional intake or energy expenditure.