Open AccessTime-of-day-dependent dietary fat consumption influences multiple cardiometabolic syndrome parameters in mice
Author(s) -
Molly S. Bray,
Ju-Yun Tsai,
Carolina Villegas-Montoya,
Brandon B. Boland,
Zackary Blasier,
Oluwaseun Egbejimi,
Michael Kueht,
Martin E. Young
Publication year - 2010
Publication title -
international journal of obesity
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/ijo.2010.63
Subject(s) - hyperinsulinemia , calorie , metabolic syndrome , endocrinology , medicine , insulin resistance , glucose homeostasis , dyslipidemia , saturated fat , weight gain , ingestion , meal , hypertriglyceridemia , obesity , triglyceride , cholesterol , body weight
Excess caloric intake is strongly associated with the development of increased adiposity, glucose intolerance, insulin resistance, dyslipidemia, and hyperleptinemia (that is the cardiometabolic syndrome). Research efforts have focused attention primarily on the quality (that is nutritional content) and/or quantity of ingested calories as potential causes for diet-induced pathology. Despite growing acceptance that biological rhythms profoundly influence energy homeostasis, little is known regarding how the timing of nutrient ingestion influences development of common metabolic diseases.