Open AccessChronic exposure to a high-fat diet affects stress axis function differentially in diet-induced obese and diet-resistant rats
Author(s) -
Andrew C. Shin,
Sheba M.J. MohanKumar,
Madhu P. Sirivelu,
Kate J. Claycombe,
Joseph R. Haywood,
Gregory D. Fink,
P.S. MohanKumar
Publication year - 2010
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/ijo.2010.34
Subject(s) - medicine , endocrinology , leptin , hypothalamus , corticosterone , glucocorticoid receptor , median eminence , corticotropin releasing hormone , tyrosine hydroxylase , catecholamine , receptor , hormone , chemistry , obesity , dopamine
Consumption of a high-fat (HF) diet is a contributing factor for the development of obesity. HF diet per se acts as a stressor, stimulating hypothalamo-pituitary-adrenal (HPA) axis activity resulting in elevated glucocorticoid levels; however, the mechanism behind this activation is unclear. We hypothesized that consumption of an HF diet activates HPA axis by increasing norepinephrine (NE) in the paraventricular nucleus (PVN) of the hypothalamus, leading to elevation in corticotrophin-releasing hormone (CRH) concentration in the median eminence (ME) resulting in elevated serum corticosterone (CORT).