Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity | Zendy

Claire Lagathu | Zendy; C Christodoulides | Zendy; Chong Yew Tan | Zendy; Sam Virtue | Zendy; Matthias Laudes | Zendy; Mark Campbell | Zendy; Ko Ishikawa | Zendy; Francisco Ortega | Zendy; Francisco J. Tinahones | Zendy; José Manuel FernándezReal | Zendy; Matej Orešič | Zendy; Jaswinder K. Sethi | Zendy; António Vidal-Puig | Zendy

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Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity

Author(s) -

Claire Lagathu,

C Christodoulides,

Chong Yew Tan,

Sam Virtue,

Matthias Laudes,

Mark Campbell,

Ko Ishikawa,

Francisco Ortega,

Francisco J. Tinahones,

José Manuel FernándezReal,

Matej Orešič,

Jaswinder K. Sethi,

António Vidal-Puig

Publication year - 2010

Publication title -

international journal of obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.663

H-Index - 225

eISSN - 1476-5497

pISSN - 0307-0565

DOI - 10.1038/ijo.2010.107

Subject(s) - adipogenesis , adipose tissue , wnt signaling pathway , endocrinology , medicine , biology , frizzled , paracrine signalling , microbiology and biotechnology , ectopic expression , signal transduction , receptor , cell culture , genetics

The Wnt/β-catenin signaling network offers potential targets to diagnose and uncouple obesity from its metabolic complications. In this study, we investigate the role of the Wnt antagonist, secreted frizzled-related protein 1 (SFRP1), in promoting adipogenesis in vitro and adipose tissue expansion in vivo.

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