The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity | Zendy

Imo J. Akpan | Zendy; Marcus D. Goncalves | Zendy; Rajiv Dhir | Zendy; Xiaoyan Yin | Zendy; Emidio E. Pistilli | Zendy; Sasha Bogdanovich | Zendy; Tejvir S. Khurana | Zendy; J Ucran | Zendy; J Lachey | Zendy; Rexford S. Ahima | Zendy

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The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

Author(s) -

Imo J. Akpan,

Marcus D. Goncalves,

Rajiv Dhir,

Xiaoyan Yin,

Emidio E. Pistilli,

Sasha Bogdanovich,

Tejvir S. Khurana,

J Ucran,

J Lachey,

Rexford S. Ahima

Publication year - 2009

Publication title -

international journal of obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.663

H-Index - 225

eISSN - 1476-5497

pISSN - 0307-0565

DOI - 10.1038/ijo.2009.162

Subject(s) - medicine , endocrinology , myostatin , insulin , adiponectin , activin receptor , adiponectin receptor 1 , receptor , insulin receptor , fgf21 , glucose uptake , biology , insulin resistance , chemistry , fibroblast growth factor , muscle hypertrophy

Myostatin, also known as Growth and Differentiation Factor 8, is a secreted protein that inhibits muscle growth. Disruption of myostatin signaling increases muscle mass and decreases glucose, but it is unclear whether these changes are related. We treated mice on chow and high-fat diets with a soluble activin receptor type IIB (ActRIIB, RAP-031), which is a putative endogenous signaling receptor for myostatin and other ligands of the TGF-beta superfamily.

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