Open AccessDepot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue
Author(s) -
Robert W. O’Rourke,
Monja D. Metcalf,
Ashley E. White,
Akhila Madala,
Brian Winters,
Ilan I. Maizlin,
Blair A. Jobe,
Charles T. Roberts,
Mark K. Slifka,
Daniel L. Marks
Publication year - 2009
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/ijo.2009.133
Subject(s) - adipose tissue , inflammation , proinflammatory cytokine , tumor necrosis factor alpha , adipose tissue macrophages , cytokine , biology , immunology , medicine , endocrinology , white adipose tissue
Adipose tissue is a primary in vivo site of inflammation in obesity. Excess visceral adipose tissue (VAT), when compared to subcutaneous adipose tissue (SAT), imparts an increased risk of obesity-related comorbidities and mortality, and exhibits differences in inflammation. Defining depot-specific differences in inflammatory function may reveal underlying mechanisms of adipose-tissue-based inflammation.