Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue | Zendy

Robert W. O’Rourke | Zendy; Monja D. Metcalf | Zendy; Ashley E. White | Zendy; Akhila Madala | Zendy; Brian R. Winters | Zendy; Ilan I. Maizlin | Zendy; Blair A. Jobe | Zendy; Charles T. Roberts | Zendy; Mark K. Slifka | Zendy; Daniel L. Marks | Zendy

Open Access

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

Author(s) -

Robert W. O’Rourke,

Monja D. Metcalf,

Ashley E. White,

Akhila Madala,

Brian R. Winters,

Ilan I. Maizlin,

Blair A. Jobe,

Charles T. Roberts,

Mark K. Slifka,

Daniel L. Marks

Publication year - 2009

Publication title -

international journal of obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.663

H-Index - 225

eISSN - 1476-5497

pISSN - 0307-0565

DOI - 10.1038/ijo.2009.133

Subject(s) - adipose tissue , inflammation , proinflammatory cytokine , tumor necrosis factor alpha , adipose tissue macrophages , cytokine , biology , immunology , medicine , endocrinology , white adipose tissue

Adipose tissue is a primary in vivo site of inflammation in obesity. Excess visceral adipose tissue (VAT), when compared to subcutaneous adipose tissue (SAT), imparts an increased risk of obesity-related comorbidities and mortality, and exhibits differences in inflammation. Defining depot-specific differences in inflammatory function may reveal underlying mechanisms of adipose-tissue-based inflammation.

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