Open AccessRisk of new tumors in von Hippel–Lindau patients depends on age and genotype
Author(s) -
Marie Louise Mølgaard Binderup,
Esben BudtzJørgensen,
Marie Luise Bisgaard
Publication year - 2015
Publication title -
genetics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.509
H-Index - 128
eISSN - 1530-0366
pISSN - 1098-3600
DOI - 10.1038/gim.2015.44
Subject(s) - medicine , genotype , confidence interval , cohort , hazard ratio , poisson regression , missense mutation , oncology , pediatrics , physiology , mutation , genetics , biology , population , environmental health , gene
The von Hippel-Lindau (vHL) phenotype is variable, which complicates genetic counseling and surveillance. We describe how the rate of new tumor development varies through the lifetimes of vHL patients and how it is influenced by age and genotype.
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