Savior siblings and Fanconi anemia: analysis of success rates from the family’s perspective | Zendy

Juan Pablo TrujilloQuintero | Zendy; Jordi Surrallés | Zendy

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Savior siblings and Fanconi anemia: analysis of success rates from the family’s perspective

Author(s) -

Juan Pablo TrujilloQuintero,

Jordi Surrallés

Publication year - 2015

Publication title -

genetics in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.509

H-Index - 128

eISSN - 1530-0366

pISSN - 1098-3600

DOI - 10.1038/gim.2014.206

Subject(s) - fanconi anemia , savior sibling , medicine , human leukocyte antigen , anemia , in vitro fertilisation , embryo , immunology , hematopoietic stem cell transplantation , biology , transplantation , genetics , antigen , gene , dna repair

The current curative treatment of Fanconi anemia is hematopoietic stem cell transplantation; this treatment has a higher rate of successful outcome when donors are compatible siblings. Therefore some families opt to have a healthy and compatible baby after selecting an embryo using preimplantation genetic diagnosis with human leukocyte antigen (HLA) typing. This study aims to estimate the success rate of this procedure from the family's perspective.

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