Inbreeding among Caribbean Hispanics from the Dominican Republic and its effects on risk of Alzheimer disease | Zendy

Badri N. Vardarajan | Zendy; Daniel J. Schaid | Zendy; Christiane Reitz | Zendy; Rafael Lantigua | Zendy; Martin Medrano | Zendy; Ivonne Z. JiménezVelázquez | Zendy; Joseph H. Lee | Zendy; Mahdi Ghani | Zendy; Ekaterina Rogaeva | Zendy; Peter St GeorgeHyslop | Zendy; Richard Mayeux | Zendy

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Inbreeding among Caribbean Hispanics from the Dominican Republic and its effects on risk of Alzheimer disease

Author(s) -

Badri N. Vardarajan,

Daniel J. Schaid,

Christiane Reitz,

Rafael Lantigua,

Martin Medrano,

Ivonne Z. JiménezVelázquez,

Joseph H. Lee,

Mahdi Ghani,

Ekaterina Rogaeva,

Peter St GeorgeHyslop,

Richard Mayeux

Publication year - 2014

Publication title -

genetics in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.509

H-Index - 128

eISSN - 1530-0366

pISSN - 1098-3600

DOI - 10.1038/gim.2014.161

Subject(s) - inbreeding , runs of homozygosity , biology , genetics , disease , consanguinity , genotype , allele , inbreeding depression , population , alzheimer's disease , single nucleotide polymorphism , demography , medicine , gene , sociology

Inbreeding can be associated with a modification of disease risk due to excess homozygosity of recessive alleles affecting a wide range of phenotypes. We estimated the inbreeding coefficient in Caribbean Hispanics and examined its effects on risk of late-onset Alzheimer disease.

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