Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization | Zendy

Jennifer Laffin | Zendy; Gordana Raca | Zendy; Craig Jackson | Zendy; Edythe A. Strand | Zendy; Kathy J. Jakielski | Zendy; Lawrence D. Shriberg | Zendy

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Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization

Author(s) -

Jennifer Laffin,

Gordana Raca,

Craig Jackson,

Edythe A. Strand,

Kathy J. Jakielski,

Lawrence D. Shriberg

Publication year - 2012

Publication title -

genetics in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.509

H-Index - 128

eISSN - 1530-0366

pISSN - 1098-3600

DOI - 10.1038/gim.2012.72

Subject(s) - apraxia , genetics , comparative genomic hybridization , copy number variation , biology , foxp2 , audiology , chromosome , psychology , gene , medicine , genome , aphasia , neuroscience , transcription factor

The goal of this study was to identify new candidate genes and genomic copy-number variations associated with a rare, severe, and persistent speech disorder termed childhood apraxia of speech. Childhood apraxia of speech is the speech disorder segregating with a mutation in FOXP2 in a multigenerational London pedigree widely studied for its role in the development of speech-language in humans.

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