Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease | Zendy

Ahmed M. Moustafa | Zendy; Weizhong Li | Zendy; Ericka L. Anderson | Zendy; Emily H. M. Wong | Zendy; Parambir S. Dulai | Zendy; William J. Sandborn | Zendy; William Biggs | Zendy; Shibu Yooseph | Zendy; Marcus B. Jones | Zendy; Craig Venter | Zendy; William Nelson | Zendy; John T. Chang | Zendy; Amalio Telenti | Zendy; Brigid S. Boland | Zendy

Open Access

Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease

Author(s) -

Ahmed M. Moustafa,

Weizhong Li,

Ericka L. Anderson,

Emily H. M. Wong,

Parambir S. Dulai,

William J. Sandborn,

William Biggs,

Shibu Yooseph,

Marcus B. Jones,

Craig Venter,

William Nelson,

John T. Chang,

Amalio Telenti,

Brigid S. Boland

Publication year - 2018

Publication title -

clinical and translational gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.673

H-Index - 35

ISSN - 2155-384X

DOI - 10.1038/ctg.2017.58

Subject(s) - microbiome , metagenomics , dysbiosis , inflammatory bowel disease , immunology , ulcerative colitis , crohn's disease , medicine , genome wide association study , disease , gut flora , human leukocyte antigen , single nucleotide polymorphism , biology , bioinformatics , genetics , genotype , gene , antigen

We show that genetic risk may have a role in early risk stratification in the care of IBD patients and propose that expression of virulence factors in a dysbiotic microbiome may contribute to pathogenesis in IBD.

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