Circulating Soluble CD163 is Associated with Steatohepatitis and Advanced Fibrosis in Nonalcoholic Fatty Liver Disease | Zendy

Jessica L. Mueller | Zendy; Eoin R. Feeney | Zendy; Hui Zheng | Zendy; Joseph Misdraji | Zendy; Annie J. Kruger | Zendy; Nadia Alatrakchi | Zendy; Lindsay Y. King | Zendy; Louis G. Gelrud | Zendy; Kathleen E. Corey | Zendy; Raymond T. Chung | Zendy

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Circulating Soluble CD163 is Associated with Steatohepatitis and Advanced Fibrosis in Nonalcoholic Fatty Liver Disease

Author(s) -

Jessica L. Mueller,

Eoin R. Feeney,

Hui Zheng,

Joseph Misdraji,

Annie J. Kruger,

Nadia Alatrakchi,

Lindsay Y. King,

Louis G. Gelrud,

Kathleen E. Corey,

Raymond T. Chung

Publication year - 2015

Publication title -

clinical and translational gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.673

H-Index - 35

ISSN - 2155-384X

DOI - 10.1038/ctg.2015.36

Subject(s) - nonalcoholic fatty liver disease , medicine , fibrosis , gastroenterology , steatosis , fatty liver , inflammation , cd163 , steatohepatitis , nonalcoholic steatohepatitis , pathology , disease , macrophage , biology , biochemistry , in vitro

In obese subjects, serum sCD163, but not sCD14, correlated with fibrosis stage and NAS. These data support a role for activated Kupffer cells in the pathogenesis of nonalcoholic steatohepatitis and fibrosis, and suggest potential clinical utility for assessment of sCD163 levels.

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