Propionyl-L-Carnitine is Efficacious in Ulcerative Colitis Through its Action on the Immune Function and Microvasculature | Zendy

Maria Giovanna Scioli | Zendy; Maria Antonietta Stasi | Zendy; Daniela Passeri | Zendy; Elena Doldo | Zendy; Gaetana Costanza | Zendy; Roberto Camerini | Zendy; Paolo Fociani | Zendy; Gaetano Arcuri | Zendy; Katia Lombardo | Zendy; Silvia Pace | Zendy; Franco Borsini | Zendy; Augusto Orlandi | Zendy

Open Access

Propionyl-L-Carnitine is Efficacious in Ulcerative Colitis Through its Action on the Immune Function and Microvasculature

Author(s) -

Maria Giovanna Scioli,

Maria Antonietta Stasi,

Daniela Passeri,

Elena Doldo,

Gaetana Costanza,

Roberto Camerini,

Paolo Fociani,

Gaetano Arcuri,

Katia Lombardo,

Silvia Pace,

Franco Borsini,

Augusto Orlandi

Publication year - 2014

Publication title -

clinical and translational gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.673

H-Index - 35

ISSN - 2155-384X

DOI - 10.1038/ctg.2014.4

Subject(s) - medicine , oxidative stress , ulcerative colitis , endothelial dysfunction , pharmacology , colitis , inflammation , carnitine , inflammatory bowel disease , antioxidant , nitric oxide , reactive oxygen species , immunology , biochemistry , chemistry , disease

Microvascular endothelial dysfunction characterizes ulcerative colitis (UC), the most widespread form of inflammatory bowel disease. Intestinal mucosal microvessels in UC display aberrant expression of cell adhesion molecules (CAMs) and increased inflammatory cell recruitment. Propionyl-L-carnitine (PLC), an ester of L-carnitine required for the mitochondrial transport of fatty acids, ameliorates propionyl-CoA bioavailability and reduces oxidative stress in ischemic tissues. The present study aimed to document the efficacy of anti-oxidative stress properties of PLC in counteracting intestinal microvascular endothelial dysfunction and inflammation

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