Open AccessHuman herpesvirus 6B reactivation and delirium are frequent and associated events after cord blood transplantation
Author(s) -
Joshua A. Hill,
Michael Boeckh,
Wendy Leisenring,
Hu Xie,
Amanda Adler,
MeeiLi Huang,
Jesse R. Fann,
Colleen Delaney,
Danielle M. Zerr
Publication year - 2015
Publication title -
bone marrow transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 127
eISSN - 1476-5365
pISSN - 0268-3369
DOI - 10.1038/bmt.2015.154
Subject(s) - medicine , delirium , human herpesvirus 6 , odds ratio , transplantation , hematopoietic stem cell transplantation , hazard ratio , cord blood , confidence interval , prospective cohort study , immunology , herpesviridae , viral disease , intensive care medicine , human immunodeficiency virus (hiv)
Human herpesvirus 6B (HHV-6B) frequently reactivates after cord blood transplantation (CBT). We previously reported an association between HHV-6B reactivation and delirium after hematopoietic cell transplantation. In this prospective study, 35 CBT recipients underwent twice-weekly plasma PCR testing for HHV-6 and thrice-weekly delirium assessment until day 84. There was a quantitative association between HHV-6B reactivation and delirium in univariable (odds ratio, 2.88; 95% confidence interval (CI), 0.97-8.59) and bivariable models. In addition, intensified prophylaxis with high-dose valacyclovir mitigated HHV-6B reactivation (adjusted hazard ratio, 0.39; 95% CI, 0.14-1.08). Larger trials are needed to explore the utility of HHV-6B prophylaxis after CBT.