Open AccessSafety of hematopoietic stem cell donation in glucose 6 phosphate dehydrogenase-deficient donors
Author(s) -
Federica Pilo,
D Baronciani,
Cristina Depau,
Clara Targhetta,
Mario Pani,
R Manconi,
Maurizio Fadda,
Angela Maria Mamusa,
Emanuele Angelucci
Publication year - 2012
Publication title -
bone marrow transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 127
eISSN - 1476-5365
pISSN - 0268-3369
DOI - 10.1038/bmt.2012.112
Subject(s) - medicine , haematopoiesis , donation , hematopoietic stem cell transplantation , stem cell , transplantation , hematopoietic stem cell , surgery , retrospective cohort study , immunology , gastroenterology , biology , economic growth , genetics , economics
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common RBC enzymatic disorder in humans capable of producing hemolytic events. Recently, concern has been raised about using G6PD-deficienct subjects as hemopoietic stem cell (HSC) donors. In a 10-year period, 101 consecutive HSC donors were submitted to donation procedures for transplantation inside their families in our Center. All donors were tested for G6PD and 19 (19%) turned out to be G6PD-deficient. The donors' safety and the effectiveness of these transplant outcomes were compared with those of the remaining 82 donors. No difference could be observed in any safety parameter between the two groups. No difference was recorded in donors' complications rates, in HSC production, in quantity of growth factor required, in Hb early drop or in Hb recovery. No difference was found in transplant outcome. From this retrospective analysis, we conclude that a G6PD-deficient but otherwise healthy volunteer can be selected as a HSC donor.