Open AccessAllo-SCT using reduced-intensity conditioning against advanced pancreatic cancer: a Japanese survey
Author(s) -
Yoshinobu Kanda,
Yasushi Omuro,
Eishi Baba,
Kiyohiro Oshima,
Koji Nagafuji,
Yuji Heike,
Yoichi Takaue,
Tsuneo Sasaki,
Hisashi Sakamaki,
Mine Harada
Publication year - 2008
Publication title -
bone marrow transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 127
eISSN - 1476-5365
pISSN - 0268-3369
DOI - 10.1038/bmt.2008.94
Subject(s) - medicine , pancreatic cancer , oncology , conditioning regimen , fludarabine , conditioning , cancer , regimen , overall survival , transplantation , gastroenterology , surgery , hematopoietic stem cell transplantation , chemotherapy , cyclophosphamide , statistics , mathematics
Pancreatic cancer is a frequent cause of cancer-related mortality and has an extremely poor prognosis. To evaluate the efficacy of allogeneic hematopoietic SCT with reduced-intensity conditioning (RICT) against pancreatic cancer, we analyzed the clinical data of 22 patients. After a fludarabine-based conditioning regimen followed by the infusion of PBSCs, all but two achieved engraftment. Complete, partial and minor response was observed in 1, 2 and 2 patients, respectively, with an overall response rate of 23%. Median survival was only 139 days and the major cause of death was tumor progression. Poor performance status before RICT and a lower number of infused CD34-positive cells were associated with shorter survival after RICT. Patients who developed chronic GVHD tended to survive longer than those who did not. These findings support the investigation of a novel treatment strategy to enhance the immunological effect against pancreatic cancer.