Germline BRCA2 mutations in men with breast cancer | Zendy

Eleni Mavraki | Zendy; IC Gray | Zendy; D. Timothy Bishop | Zendy; N.K. Spurr | Zendy

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Germline BRCA2 mutations in men with breast cancer

Author(s) -

Eleni Mavraki,

IC Gray,

D. Timothy Bishop,

N.K. Spurr

Publication year - 1997

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1997.574

Subject(s) - breast cancer , missense mutation , germline mutation , brca2 protein , germline , mutation , cancer , medicine , male breast cancer , oncology , genetics , biology , cancer research , gene

Breast cancer in men is rare and is clearly due in some cases to an inherited predisposition. A total of 28 male breast cancer patients were tested for BRCA2 mutations; two frameshifts and one putative missense mutation were identified. One of the frameshifts was detected in the same position as a mutation estimated to be responsible for 40% of all male breast cancer cases in Iceland.

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