Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro | Zendy

K. W. Colston | Zendy; SY James | Zendy; E A Ofori-Kuragu | Zendy; Lise Binderup | Zendy; A G Grant | Zendy

Open Access

Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro

Author(s) -

K. W. Colston,

SY James,

E A Ofori-Kuragu,

Lise Binderup,

A G Grant

Publication year - 1997

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1997.501

Subject(s) - in vivo , in vitro , pancreatic cancer , medicine , endocrinology , hypercalcaemia , vitamin , vitamin d and neurology , receptor , carcinoma , cell growth , cancer research , cell culture , adenocarcinoma , biology , cancer , calcium , biochemistry , microbiology and biotechnology , genetics

The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 microg kg(-1) body weight i.p. thrice weekly for 4-6 weeks. Tumour growth was significantly inhibited in treated animals compared with controls in the absence of hypercalcaemia. These findings may have therapeutic implications in pancreatic cancer.

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