Prophylactic intracavitary treatment with interferon alpha increases interferon gamma production by peripheral blood mononuclear cells in patients with superficial transitional cell carcinoma of the bladder | Zendy

Luis Moltó | Zendy; Joaquı́n Carballido | Zendy; Luís Manzano | Zendy; Eduardo Reyes | Zendy; Carlos Olivier | Zendy; Melchor ÁlvarezMon | Zendy

Open Access

Prophylactic intracavitary treatment with interferon alpha increases interferon gamma production by peripheral blood mononuclear cells in patients with superficial transitional cell carcinoma of the bladder

Author(s) -

Luis Moltó,

Joaquı́n Carballido,

Luís Manzano,

Eduardo Reyes,

Carlos Olivier,

Melchor ÁlvarezMon

Publication year - 1997

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1997.315

Subject(s) - peripheral blood mononuclear cell , phytohaemagglutinin , medicine , interferon gamma , alpha interferon , cytokine , transitional cell carcinoma , interferon , pathology , urology , stimulation , immunology , bladder cancer , cancer , biology , biochemistry , in vitro

The immunomodulatory effect of prophylactic intravesical instillations of interferon alpha 2b (IFN-alpha-2b) on interferon gamma (IFN-gamma) and interleukin 4 (IL-4) production by peripheral blood mononuclear cells (PBMCs) from patients with superficial transitional cell carcinoma (STCC) of the bladder has been analysed. There were no significant differences in the production of IFN-gamma and IL-4 by PBMCs from untreated patients and healthy control subjects after 24 h of phytohaemagglutinin (PHA) stimulation. However, between 3 and 6 months after finishing the prophylactic intracavitary treatment with IFN-alpha-2b, PHA-stimulated PBMCs from patients with STCC of the bladder showed a significantly enhanced production of IFN-gamma and a significantly decreased production of IL-4. Both IFN-gamma and IL-4 returned to pretreatment levels 1 year after ending the treatment. In conclusion, prophylactic intravesical instillations of IFN-alpha-2b in patients with STCC of the bladder have an immunoregulatory effect on the production of IFN-gamma and IL-4 by PBMCs.

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