Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer | Zendy

A Lösch | Zendy; Petra Kohlberger | Zendy; G. Gitsch | Zendy; Alexandra Kaider | Zendy; G. Breitenecker | Zendy; Ch. Kainz | Zendy

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Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer

Author(s) -

A Lösch,

Petra Kohlberger,

G. Gitsch,

Alexandra Kaider,

G. Breitenecker,

Ch. Kainz

Publication year - 1996

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1996.287

Subject(s) - immunohistochemistry , cathepsin d , medicine , adenocarcinoma , endometrial cancer , oncology , univariate analysis , confidence interval , pathology , stage (stratigraphy) , multivariate analysis , cancer , biology , enzyme , paleontology , biochemistry

The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. Patients with surgically treated endometrial adenocarcinoma FIGO stages I-III and consecutive irradiation therapy were included in the study. When we performed immunohistochemistry to detect cathepsin D in 115 tissue specimens 35 cases showed a positive reaction. In the univariate analysis cathepsin D expression showed significant prognostic value for overall survival (P-value = 0.007). In the multivariate analysis with established prognostic parameters (stage, grade) we found an independent prognostic value for cathepsin D (P-value = 0.002, relative risk = 3.8, 95% confidence interval 1.4 - 10.0). Immunohistochemical detection of cathepsin D could aid in predicting prognosis and planning therapy for patients with endometrial adenocarcinoma.

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