Open AccessThe cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL
Author(s) -
Peter Nygren,
Katalin Csóka,
Bertil Jönsson,
H Fridborg,
Jonas Bergh,
Hans Hagberg,
Bengt Glimelius,
Ola Brodin,
Bengt Tholander,
A Kreuger
Publication year - 1995
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/bjc.1995.97
Subject(s) - paclitaxel , in vitro , cytotoxic t cell , pharmacology , cytotoxicity , ethanol , chemistry , cell culture , biological activity , chemotherapy , cancer research , medicine , biology , biochemistry , genetics
In patient tumour samples the activity in vitro of Taxol corresponded fairly well to the known clinical activity and Taxol showed low cross-resistance to standard cytotoxic drugs. However, the Taxol solvent Cremophor EL--ethanol was considerably active alone, whereas paclitaxel formulated in ethanol was less active. Taxol thus seems to contain two components active against patient tumour cells in vitro.