The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL | Zendy

Peter Nygren | Zendy; K Csóka | Zendy; Bertil Jönsson | Zendy; H Fridborg | Zendy; Jonas Bergh | Zendy; Hans Hagberg | Zendy; Ingrid Glimelius | Zendy; Ola Brodin | Zendy; Bengt Tholander | Zendy; A Kreuger | Zendy; Gudmar Lönnerholm | Zendy; Andreas Jakobsson | Zendy; Lene C. Olsen | Zendy; Jörgen Kristensen | Zendy; Rolf Larsson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL

Author(s) -

Peter Nygren,

K Csóka,

Bertil Jönsson,

H Fridborg,

Jonas Bergh,

Hans Hagberg,

Ingrid Glimelius,

Ola Brodin,

Bengt Tholander,

A Kreuger,

Gudmar Lönnerholm,

Andreas Jakobsson,

Lene C. Olsen,

Jörgen Kristensen,

Rolf Larsson

Publication year - 1995

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1995.97

Subject(s) - paclitaxel , in vitro , cytotoxic t cell , pharmacology , cytotoxicity , ethanol , chemistry , cell culture , biological activity , chemotherapy , cancer research , medicine , biology , biochemistry , genetics

In patient tumour samples the activity in vitro of Taxol corresponded fairly well to the known clinical activity and Taxol showed low cross-resistance to standard cytotoxic drugs. However, the Taxol solvent Cremophor EL--ethanol was considerably active alone, whereas paclitaxel formulated in ethanol was less active. Taxol thus seems to contain two components active against patient tumour cells in vitro.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research