Inheritance and testicular cancer | Zendy

P. W. Nicholson | Zendy; S. J. Harland | Zendy

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Inheritance and testicular cancer

Author(s) -

P. W. Nicholson,

S. J. Harland

Publication year - 1995

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1995.86

Subject(s) - genetic predisposition , disease , testicular cancer , inheritance (genetic algorithm) , cancer , medicine , hereditary diseases , genetics , biology , pathology , gene

Statistical analysis of published data on the age of onset of germ cell tumours of the testis and of the prevalence of bilateral disease in familial and general cases suggest the following: 1. Patients with bilateral disease carry the same genetic predisposition as familial cases. 2. Males with the hereditary predisposition develop none, unilateral or bilateral tumours in the proportions 55%, 38% and 7% respectively. 3. One-third of all testis cancer patients are genetically predisposed to the disease. 4. The 2.2% risk to brothers of cases as reported elsewhere can be accounted for by the homozygous (recessive) inheritance of a single predisposing gene.

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