Open AccessCorrelation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma
Author(s) -
Y. Kakeji,
Yoshihiko Maehara,
Masaru Morita,
Akito Matsukuma,
Motonosuke Furusawa,
Ikuo Takahashi,
Tetsuya Kusumoto,
Shinji Ohno,
Keizō Sugimachi
Publication year - 1995
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/bjc.1995.39
Subject(s) - proliferating cell nuclear antigen , pathology , antigen , staining , lymph node , metastasis , immunohistochemistry , medicine , carcinoma , cancer , biology , immunology
The expression of sialyl Tn (STn) antigen in 180 patients with Borrmann type IV gastric carcinomas was examined immunohistochemically. The rate of positive STn staining was 32% (57/180) for the primary tumours, and this positive staining correlated well with tumour extension, lymph node metastasis (P < 0.05) and peritoneal dissemination (P < 0.01). One-third (5/15) of patients with positive STn-staining cancer cells had a high level of serum STn. Lesions with positive STn staining were related to a lower survival rate for the patients (P < 0.05). Proliferative activity of the tumour, as measured by proliferating nuclear antigen (PCNA) labelling percentage and argyrophilic nucleolar organiser region (AgNOR) count, was significantly higher (41.5 +/- 13.0%, 3.78 +/- 0.98) in the STn-positive group than in the STn-negative group (34.2 +/- 13.2%, 3.48 +/- 0.85) (P < 0.01, P < 0.05 respectively). Estimating STn antigen may be useful for predicting the likelihood of lymph node metastasis or peritoneal dissemination and the clinical prognosis for patients with Borrmann type IV gastric carcinoma.