Open AccessProlonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody
Author(s) -
Yasuyuki Ohnishi,
Hiroyuki Nakamura,
M Yoshimura,
Yutaka Tokuda,
M Iwasawa,
Yoshito Ueyama,
Norikazu Tamaoki,
Kazuo Shimamura
Publication year - 1995
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/bjc.1995.187
Subject(s) - monoclonal antibody , cancer , epitope , antibody , cancer research , erbb , monoclonal , cancer cell , biology , medicine , immunology
A monoclonal antibody (MAb), 4D5, specifically recognising an extracellular epitope of the c-ErbB-2 protein, inhibited the growth of human gastric cancer overexpressing c-ErbB-2 severe combined immunodeficient (SCID) mice. This antibody also reduced the mass of established tumours xenografted into SCID mice, whereas gastric cancer not expressing c-ErbB-2 exhibited no regression in response to 4D5 treatment. In addition, administration of 4D5 prevented colonisation of cancer cells and prolonged the survival of host SCID mice inoculated i.v. with c-ErbB-2-overexpressing tumour cells. This is the first reported study to show that treatment with a single antibody specific to c-ErbB-2 prolongs the survival of host SCID mice bearing xenotransplanted tumours.