Open AccessAccumulation of natural killer cells after hepatic artery embolisation in the midgut carcinoid syndrome
Author(s) -
Bo Wängberg,
Håkan Ahlman,
Ulf Tylén,
Ola Nilsson,
Svante Hermodsson,
Kristoffer Hellstrand
Publication year - 1995
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/bjc.1995.120
Subject(s) - lymphocytosis , midgut , medicine , pathology , carcinoid syndrome , biology , botany , larva
Eleven patients with disseminated midgut carcinoid tumour disease were subjected to hepatic artery embolisation. In six patients, lymphocytosis with a predominance of NK cells occurred and the cytotoxic activity of isolated lymphocytes increased. A relation between NK cell accumulation and subsequent radiological and biochemical response was observed, and it is suggested that anti-tumour mechanisms other than ischaemia may contribute to the therapeutic response in these patients.