Infrequent chromosome allele loss in fibrolamellar carcinoma | Zendy

S-F Ding | Zendy; JDA Delhanty | Zendy; L Bowles | Zendy; JS Dooley | Zendy; C. B. Wood | Zendy; NA Habib | Zendy

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Infrequent chromosome allele loss in fibrolamellar carcinoma

Author(s) -

S-F Ding,

JDA Delhanty,

L Bowles,

JS Dooley,

C. B. Wood,

NA Habib

Publication year - 1993

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1993.47

Subject(s) - allele , biology , hepatocellular carcinoma , loss of heterozygosity , carcinoma , genetics , chromosome , microbiology and biotechnology , pathology , cancer research , medicine , gene

As yet, there is no reported study of chromosome allele loss in fibrolamellar carcinoma (FLC), a distinct, rare variant of hepatocellular carcinoma (HCC). We searched for evidence of allele loss in FLC using 18 DNA probes for 10 chromosomes and compared the pattern of loss with our series of HCC. Two of the probes, lambda MS32 (1q42-43) and cMS621 (5p) showed allele losses in one tumour, while other probes showed no loss. The frequency of allele loss in FLC was much lower than in HCC, which may be associated with their different prognoses.

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