Open AccessStructural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture)
Author(s) -
Livingston Dm,
William G. Kaelin,
Thomas Chittenden,
Qin Xin
Publication year - 1993
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/bjc.1993.325
Subject(s) - retinoblastoma , retinoblastoma protein , phosphorylation , cell growth , microbiology and biotechnology , cell cycle , biology , chemistry , cell , cancer research , gene , computational biology , biochemistry
The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block is lifted allowing a cell to enter S. Here, we review a series of results which speak to the elements of RB structure which contribute to this activity. Included is its internal colinear protein receptor domain (i.e. the 'pocket').