Expression of beta-2-microglobulin by nasopharyngeal carcinoma | Zendy

W. Shiu | Zendy; SF Leung | Zendy; WT Leung | Zendy; Simone S.M. Ho | Zendy; Meimei Tao | Zendy

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Expression of beta-2-microglobulin by nasopharyngeal carcinoma

Author(s) -

W. Shiu,

SF Leung,

WT Leung,

Simone S.M. Ho,

Meimei Tao

Publication year - 1992

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1992.313

Subject(s) - nasopharyngeal carcinoma , beta 2 microglobulin , beta (programming language) , stage (stratigraphy) , carcinoma , medicine , disease , gastroenterology , pathology , oncology , radiation therapy , biology , paleontology , computer science , programming language

Serum beta-2-microglobulin (beta 2M) levels of 274 Chinese patients with different stages of nasopharyngeal carcinoma at presentation and that of 35 patients who developed distant metastases post-treatment were assayed. beta 2M level was found to increase with advancing stage of disease, with statistically significant differences among early-stage, advanced-stage, and metastatic disease. Elevated pre-treatment beta 2M levels were expressed more frequently by tumours with lower degree of histological differentiation. The sensitivity of serum beta 2M for diagnosis of nasopharyngeal carcinoma, however, is low.

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