Open AccessAntigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-α
Author(s) -
Patrizio Giacomini,
Marcella Mottolese,
Rocco Fraioli,
Maria Benevolo,
Irene Venturo,
Pier Giorgio Natali
Publication year - 1992
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/bjc.1992.267
Subject(s) - ovary , antigen , breast carcinoma , carcinoma , pathology , ovarian carcinoma , histocompatibility , medicine , biology , cancer research , immunology , breast cancer , cancer , human leukocyte antigen , ovarian cancer
Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.