Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-α | Zendy

Patrizio Giacomini | Zendy; Marcella Mottolese | Zendy; Rocco Fraioli | Zendy; Maria Benevolo | Zendy; Irene Venturo | Zendy; PG Natali | Zendy

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Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-α

Author(s) -

Patrizio Giacomini,

Marcella Mottolese,

Rocco Fraioli,

Maria Benevolo,

Irene Venturo,

PG Natali

Publication year - 1992

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1992.267

Subject(s) - ovary , antigen , breast carcinoma , carcinoma , pathology , ovarian carcinoma , histocompatibility , medicine , biology , cancer research , immunology , breast cancer , cancer , human leukocyte antigen , ovarian cancer

Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.

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