Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features | Zendy

PJ Hainsworth | Zendy; KL Raphael | Zendy; RG Stillwell | Zendy; R C Bennett | Zendy; O. Margaret Garson | Zendy

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Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features

Author(s) -

PJ Hainsworth,

KL Raphael,

RG Stillwell,

R C Bennett,

O. Margaret Garson

Publication year - 1992

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1992.229

Subject(s) - exact test , chromosomal translocation , mann–whitney u test , biology , breast cancer , chromosome , cytogenetics , cancer , estrogen receptor , breakpoint , medicine , oncology , pathology , genetics , gene

In a cytogenetic study of breast cancer biopsies, clonal abnormalities of chromosome 1p were identified in 56% (14) of 25 informative patients. Translocations predominated, involving 1p22 (n = 1), 1p35 (n = 1) or 1p36 (n = 10) breakpoints. Chromosome 1p abnormalities were associated with estrogen receptor (ER) negativity (P = 0.03, 2-tailed Fisher Exact Probability test), high histological grade (P = 0.02, 2-tailed Mann-Whitney U-test) and an unfavourable Melbourne Prognostic Score (NEPA P = 0.02, SEPA P = 0.04, 2-tailed Mann-Whitney U-tests). These findings are consistent with the possibility that a gene located on chromosome 1p is implicated in tumour progression.

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